Top Picks: Hypoallergenic Pillow Covers to Improve Sleep

Jun 9, 2025

Written by: Pacagen Team
Reviewed by: Evan Zhao, PhD
Evan is a bioengineer, a loving dad to Miao Miao, and the founder and CEO of Pacagen.

Allergies can significantly disrupt a good night's sleep, leading to fatigue and decreased quality of life. For many, the culprit lies within their bedding — specifically, their pillows. Dust mites , pet dander, and other allergens accumulate in pillow fibers, triggering allergic reactions. A simple yet effective solution to this problem is hypoallergenic pillow covers. In this blog, we'll explore how these covers can transform your sleep experience and provide relief from common allergens.

Understanding hypoallergenic materials

Hypoallergenic pillow covers are made from materials designed to repel common allergens. Fabrics like tightly woven cotton, microfiber, and bamboo are popular choices because they effectively block dust mites and other particles. Some covers also come with antimicrobial treatments to prevent the growth of mold and bacteria. By acting as a barrier between you and potential allergens, these materials help reduce allergic reactions during sleep and improve your sleep quality.

Top features to look for in hypoallergenic pillow covers

When selecting a hypoallergenic pillow cover, consider the following features:

Breathability: This ensures comfort by allowing air circulation while blocking allergens
Ease of cleaning: Machine-washable covers are easy to maintain, ensuring that allergen build-up is regularly removed
Durability: High-quality materials withstand frequent washing without degrading, so the cover maintains its protective qualities over time

Investing in a cover with these features can enhance both comfort and allergy protection.

Hypoallergenic pillow covers

Product recommendations

Based on customer reviews and expert opinions, here are some top-rated hypoallergenic pillow covers:

1. AllerEase Maximum Allergy Protection Zippered Pillow Protector

Features a tightly woven fabric that blocks allergens
Machine washable and durable
Price: Approximately $15 for a set of two

2. SafeRest Premium Hypoallergenic Waterproof Pillow Protector

Combines allergen protection with waterproofing
Soft terry cotton surface for comfort
Price: Approximately $20 per cover

3. National Allergy 100% Cotton Zippered Pillow Cover

Made from 100% cotton with a tight weave
Recommended by allergists
Price: Approximately $25 for a set of two

These products offer a range of features and price points to suit different needs and budgets.

Additional tips for allergy-proofing your bedroom

Beyond pillow covers, consider these strategies to minimize allergens in your bedroom:

Use allergy-friendly air purifiers: Devices with HEPA filters can capture airborne allergens, improving overall air quality
Regular cleaning: Wash bedding weekly in hot water and vacuum carpets and curtains regularly to remove dust and dander. Consider adding Pacagen Dust Allergen Neutralizing Spray to your cleaning routine
Keep pets off your bed: Designate your bed as a pet-free zone to reduce pet dander build-up on your bedding
Opt for hypoallergenic bedding: Mattress encasements and comforters designed to repel allergens can further enhance your sleep environment

Implementing these measures can create a comprehensive approach to managing bedroom allergens.

Conclusion

Hypoallergenic pillow covers are a simple but powerful way to tackle nighttime allergy attacks. When you know what materials and features offer the best protection, you can choose the right covers to improve your sleep. Pair them with other allergy-proofing tips, and you'll be well on your way to reducing allergens in your bedroom. Check out our product recommendations to find the perfect fit and take the first step toward better, allergy-free sleep.