The Next-Generation of Allergen Management: Our Results
Written by: Pacagen Team
Reviewed by: Yang Li, PhD
Yang is a physicist, pet parent, and a scientist at Pacagen.
Picture this: your child is playing on the carpet. The cat jumps on the couch. Guests come over, and within minutes someone is sneezing. No matter how often you clean, the allergies keep coming back. Pills may give temporary relief, but the problem always returns.
So we asked ourselves a simple question: Can a home truly be allergen-free, so everyone can breathe with ease?
That question drove the creation of our two breakthrough solutions: WhiskerBlock™ for pet allergens and EnviroBlock™ for dust mite allergens. Unlike conventional approaches, these proteins work in your environment so kids can cuddle with pets and guests can relax without a box of tissues nearby.
For this innovation to matter, it had to meet three strict criteria:
- Act directly on allergens where they build up.
- Deliver rapid, measurable results.
- Handle even the toughest allergens that go beyond simple immune triggers.
We don’t make claims lightly. Our science backs every word - here’s what the results show. In part 3 of our four part series, we discuss the studies undertaken to validate our WhiskerBlock™ and EnviroBlock™ technology.
WhiskerBlock™: Fast and Powerful Relief from Pet Allergens
When you take a pill for pain or an antibiotic, you expect results in hours or days. But allergens demand a faster solution. Is it possible to get rid of them in real time?
That’s exactly what WhiskerBlock™ does. Because allergens are themselves proteins, our engineered molecules can “click” into place on them with remarkable precision - much like fitting the right puzzle piece. In laboratory studies, WhiskerBlock™ locked onto allergens within minutes, completely neutralizing them.
And it doesn’t take much. Clear results appeared at concentrations as low as 150 ng/mL, with full efficacy at about 3 μg/mL - an amount smaller than a droplet of water.
That speed and efficiency put WhiskerBlock™ and EnviroBlock™ in a different league compared to conventional medications, which must circulate through the entire body before providing relief hours later.
What’s more, the WhiskerBlock™ goes beyond simply binding to allergens. Take cat allergens Fel d 1 as an example. Fel d 1 is a small but stubborn protein produced in cat saliva and sebaceous glands. Every time a cat grooms, Fel d 1 coats its fur, and from there it spreads onto couches, carpets, curtains, clothing, and the air you breathe.
Fel d 1 is so difficult to deal with because of its structure. Rather than floating around as a single protein, Fel d 1 assembles into a tetramer - four identical subunits that lock together into a compact, highly stable shape. This tetramer doesn’t just make Fel d 1 ‘sticky’ - it gives it remarkable staying power. Once released, it can persist on surfaces for months, even years. That’s why half of all homes without a cat still test positive for Fel d 1.
This makes Fel d 1 an ideal trigger for allergies. But this is no longer a challenge with WhiskerBlock™.
How does it work? WhiskerBlock™ recognizes Fel d 1 at precise molecular contact points, attaches itself, and destabilizes up to 98% of the tetramer. Once disrupted, the four subunits fall apart into smaller, unstable fragments. See video:
These fragments lose the ability to activate key immune receptors (FceRI receptors), meaning crucial immune cells, like mast cells, remain silent and no surge in histamine occurs. In other words, the protein that once triggered allergic cascades becomes harmless.
EnviroBlock™: Double Protection Against Dust Mite Allergens
If cat dander is stubborn, dust mites are relentless. Invisible and unavoidable, they leave behind allergenic proteins in their feces that accumulate bedding, carpets, and upholstery. The most notorious are Der p 1 and Der p 2. Unlike simple allergens that only trigger immune recognition, these proteins are also biologically active, meaning that they actively worsen allergic reactions.
Der p 1, for example, is a cysteine protease that can break down protective proteins in your airway lining, weakening the barrier between you and the outside environment. This makes it easier for allergens and irritants to penetrate tissues and set off stronger immune responses.
Der p 2 has its own tricks, mimicking components of bacterial molecules and amplifying immune system activation.
In short, dust mite allergens don’t just trigger allergies - they supercharge them. This is one reason why dust mite sensitivity is strongly linked to chronic asthma and long-term respiratory inflammation.
EnviroBlock™ was engineered specifically to counter this complexity. Like WhiskerBlock™, it identifies and binds tightly to its allergen targets, neutralizing them at the molecular level, and functioning one step beyond: it blocks with their harmful biological functions.
In laboratory studies, EnviroBlock™ blocked up to 93% of these secondary activities. That means not only are the allergens broken down, but their ability to weaken barriers or mimic immune triggers is shut down. This dual-action defense offers a level of protection that cleaning, filters, or medications alone simply cannot provide.
For households, the difference is clear: fewer nighttime wheezing episodes, better sleep, reduced morning congestion, and a healthier environment overall. By addressing the allergen at its root, EnviroBlock™ turns a long-standing battle with dust mites into a manageable, science-driven solution.
The Pacagen Advantage
WhiskerBlock™ and EnviroBlock™ represent a new chapter in allergen management. They are not treatments that alter your immune system or temporarily mask symptoms. They are environmental solutions that eliminate allergens before they reach you.
- Speed: neutralization within minutes, not hours.
- Strength: efficacy at vanishingly small doses.
- Functional: breaks down allergens and blocks their biological activity as dual protection.
And the benefits extend to everyone in the household: children, sensitive family members, even visiting friends. With allergens removed at the source, everyone breathes easier.
With Pacagen, the fight against allergies moves from reactive treatment to proactive prevention - a science-driven solution built for everyday life. Interested in reading more about our research?